:root{--canvas:#f3f4f5;--surface:#fcfcfd;--surface-raised:#eef0f2;--surface-hover:#e5e9ed;--input-surface:#fff;--stroke:#d5dbe1;--stroke-strong:#8794a1;--text:#242a31;--text-muted:#52606d;--text-soft:#5b6670;--brand:#265f91;--brand-hover:#19486f;--on-brand:#fff;--accent-soft:#e7eff6;--success:#2d6547;--success-soft:#edf5ef;--success-stroke:#a0b8a9;--warning:#755b22;--warning-soft:#faf6e9;--warning-stroke:#c4b58c;--danger:#ac3434;--danger-soft:#faeded;--scroll-thumb:#abb5be;--shadow-color:#25303b0b;--mint:var(--brand);--blue:#466b93;--amber:#94601e;--lightningcss-light:initial;--lightningcss-dark: ;color-scheme:light;color:var(--text);background:var(--canvas);font-synthesis:none;text-rendering:optimizelegibility;-webkit-font-smoothing:antialiased;font-family:Inter,-apple-system,BlinkMacSystemFont,Segoe UI,PingFang SC,Microsoft YaHei,sans-serif}*{box-sizing:border-box}html{scroll-behavior:smooth;scrollbar-color:var(--scroll-thumb) var(--canvas)}body{min-width:320px;margin:0}a{color:inherit;text-decoration:none}button,input,select{font:inherit}button,a,input,select,summary{-webkit-tap-highlight-color:transparent}button,select,summary{cursor:pointer}:is(button,a,input,select,summary):focus-visible{outline:2px solid var(--mint);outline-offset:3px}select{border:1px solid var(--stroke);color:var(--text);background:var(--surface);border-radius:7px;padding:8px 10px}input::placeholder{color:var(--text-soft)}button:disabled{cursor:not-allowed;opacity:.55}::selection{color:#193a55;background:#d0e2f0}.sr-only{clip:rect(0,0,0,0);white-space:nowrap;border:0;width:1px;height:1px;margin:-1px;padding:0;position:absolute;overflow:hidden}.skip-link{z-index:100;background:var(--surface-raised);color:var(--text);border:1px solid var(--mint);border-radius:7px;padding:12px 20px;position:fixed;top:8px;left:8px;transform:translateY(-150%)}.skip-link:focus{transform:translateY(0)}.app{--ink:var(--text);--muted:var(--text-muted);--accent:var(--brand);--line:var(--stroke);min-height:100vh;color:var(--ink);display:flex}.sidebar{background:var(--surface);width:226px;color:var(--text-muted);z-index:20;flex-direction:column;padding:31px 20px 0;display:flex;position:fixed;inset:0 auto 0 0}.brand{color:var(--text);align-items:center;gap:11px;margin:0 4px 34px;display:flex}.brand-logo{object-fit:contain;flex:none;width:42px;height:42px}.brand-name{letter-spacing:-.045em;font-family:Avenir Next,Segoe UI Variable,Helvetica Neue,sans-serif;font-size:18px;line-height:1.02;display:grid}.brand-primary{font-weight:750}.brand-secondary{letter-spacing:-.035em;font-weight:500}.nav-label{letter-spacing:1px;color:var(--text-muted);justify-content:space-between;margin:0 12px 12px;font-size:13px;display:flex}.nav-item{border-radius:7px;align-items:center;gap:12px;margin-bottom:5px;padding:13px;font-size:14px;transition:background .2s;display:flex}.nav-item:hover{background:var(--surface-hover);color:var(--text-muted)}.nav-item.active{background:var(--accent-soft);color:var(--brand)}.nav-guide{width:100%;color:inherit;text-align:left;cursor:pointer;background:0 0;border:0;font-family:inherit}.nav-dot{background:#b7a1ef;border-radius:50%;width:5px;height:5px;margin-left:auto}.sidebar-divider{background:var(--surface);height:1px;margin:22px 10px 25px}.presets button{text-align:left;width:100%;color:var(--text-muted);background:0 0;border:0;border-radius:7px;align-items:center;gap:11px;padding:12px;font-size:14px;display:flex}.presets button:hover{background:var(--surface-hover)}.presets small{color:var(--text-muted);margin-top:5px;font-size:13px;display:block}.presets svg{color:var(--text-muted);margin-left:auto}.preset-dot{background:#bc9fea;border-radius:50%;width:6px;height:6px}.sidebar-bottom{margin:auto 10px 25px;padding-top:45px}.small-orbit{color:var(--text-muted);font-size:32px}.sidebar-bottom h3{color:var(--text);letter-spacing:.5px;margin:12px 0;font-size:18px;font-weight:450;line-height:1.65}.sidebar-bottom p{color:var(--text-muted);margin-bottom:16px;font-size:14px;line-height:1.8}.sidebar-bottom a{color:var(--text-muted);align-items:center;gap:7px;font-size:14px;display:flex}.sidebar-footer{border-top:1px solid var(--stroke);color:var(--text-muted);align-items:center;gap:7px;padding:19px 0;font-size:12px;display:flex}.sidebar-footer>span:last-child{margin-left:auto}.main-shell{width:calc(100% - 226px);min-width:0;margin-left:226px}.topbar{background:var(--surface-raised);border-bottom:1px solid var(--line);justify-content:space-between;align-items:center;height:76px;padding:0 40px;display:flex}.breadcrumb{color:var(--text-muted);align-items:center;gap:15px;font-size:14px;display:flex}.breadcrumb strong{color:var(--text);font-weight:500}.top-actions{align-items:center;gap:24px;display:flex}.top-actions>a{color:var(--text-muted);display:flex}.demo-tag{color:var(--text-muted);letter-spacing:.7px;align-items:center;gap:7px;font-family:monospace;font-size:12px;display:flex}.demo-tag>span{background:var(--surface);border-radius:50%;width:5px;height:5px}.user-avatar{border:1px solid var(--stroke);background:var(--surface);color:var(--text-muted);border-radius:50%;place-items:center;width:31px;height:31px;font-size:14px;display:grid}main{max-width:1720px;margin:auto;padding:34px 40px 0;scroll-margin-top:20px}.page-heading{justify-content:space-between;align-items:center;gap:20px;margin-bottom:23px;display:flex}.eyebrow{letter-spacing:2px;color:var(--brand);margin:0 0 10px;font:12px/1.5 ui-monospace,SFMono-Regular,Consolas,monospace}h1{letter-spacing:1px;margin:0 0 8px;font-size:30px;font-weight:550;line-height:1.5}h1>span{color:var(--text)}.intro{color:var(--text-muted);margin:0;font-size:14px;line-height:1.8}.button{white-space:nowrap;border:1px solid #0000;border-radius:6px;justify-content:center;align-items:center;gap:9px;min-height:39px;padding:10px 15px;font-size:14px;font-weight:500;display:inline-flex}.secondary{background:var(--surface);border-color:var(--stroke);color:var(--text-muted)}.secondary:hover{border-color:var(--stroke);background:var(--surface-hover)}.demo-notice{background:var(--surface-raised);border:1px solid var(--stroke);color:var(--text-muted);border-radius:6px;align-items:center;gap:10px;margin-bottom:24px;padding:11px 15px;font-size:14px;line-height:1.7;display:flex}.demo-notice strong{font-weight:600}.demo-notice>svg{flex-shrink:0}.demo-notice a{white-space:nowrap;color:var(--text-muted);margin-left:auto}.demo-notice a>span{padding-left:4px}.workbench{grid-template-columns:258px minmax(0,1fr);align-items:start;gap:22px;display:grid}.panel{background:var(--surface);border:1px solid var(--line);border-radius:9px;overflow:hidden}.panel-heading{justify-content:space-between;align-items:center;gap:10px;padding:20px 21px;display:flex}.panel-heading h2{letter-spacing:.2px;align-items:center;gap:9px;margin:0;font-size:16px;font-weight:550;display:flex}.panel-heading p{color:var(--brand);margin:7px 0 0;font-size:13px}.config-panel>.panel-heading{border-bottom:1px solid var(--stroke);padding:19px 20px}.icon-button{width:26px;height:26px;color:var(--text-muted);background:0 0;border:0;border-radius:5px;place-items:center;display:grid}.field-group{border:0;min-width:0;margin:0 0 23px;padding:0}.field-group label,.field-group legend{align-items:center;gap:8px;width:100%;margin-bottom:12px;font-size:14px;font-weight:550;display:flex}.step{color:var(--text-muted);border:1px solid var(--stroke);border-radius:5px;place-items:center;width:21px;height:21px;font:12px monospace;display:grid}.field-group select{border-color:var(--stroke-strong);background-color:var(--input-surface);width:100%;min-height:41px;font-size:14px}.gene-select{font-family:ui-monospace,Consolas,monospace;font-weight:600}.field-hint{color:var(--text-muted);margin-top:9px;font-size:13px;display:block}.segmented{background:var(--surface-raised);border:1px solid var(--stroke);border-radius:6px;gap:3px;padding:3px;display:flex}.segmented button{color:var(--text-muted);background:0 0;border:1px solid #0000;border-radius:4px;padding:6px 12px;font-size:14px}.segmented button.selected{background:var(--accent-soft);border-color:var(--brand);box-shadow:0 1px 3px var(--shadow-color);color:var(--brand)}.mode-select button{flex:1;padding:8px 4px;font:14px ui-monospace,Consolas,monospace}.mode-select small{margin-top:6px;font-family:system-ui;font-size:12px;display:block}.range-group label{justify-content:space-between;font-weight:450}.range-group output{color:var(--text-muted);font:14px ui-monospace,Consolas,monospace}.range-group input{width:100%;accent-color:var(--brand);cursor:pointer;height:4px;margin:5px 0 9px}.range-labels{color:var(--text-muted);justify-content:space-between;font-family:monospace;font-size:12px;display:flex}.config-summary{background:var(--surface-raised);border:1px solid var(--stroke);color:var(--text-muted);border-radius:6px;align-items:center;gap:9px;margin-bottom:17px;padding:12px 10px;font-size:13px;display:flex}.config-summary small{color:var(--text-muted);margin-top:5px;font-size:12px;display:block}.config-summary>.mono{color:var(--text-muted);margin-left:auto;font-size:12px}.online-dot{background:#6da48c;border-radius:50%;flex-shrink:0;width:5px;height:5px;display:inline-block}.run-button{justify-content:space-between;width:100%;padding:11px 17px}.config-note{color:var(--text-muted);text-align:center;margin:12px -5px 0;font-size:12px;line-height:1.6}.output-column{min-width:0}.result-heading{justify-content:space-between;align-items:center;gap:10px;min-height:26px;margin:1px 0 17px;font-size:14px;display:flex}.result-heading>div{flex-wrap:wrap;align-items:center;gap:10px;display:flex}.result-heading strong{font:600 15px ui-monospace,Consolas,monospace}.outline-badge{border:1px solid var(--stroke);color:var(--text-muted);background:var(--surface);border-radius:4px;padding:3px 6px;font-size:12px}.result-status{color:var(--text-muted);white-space:nowrap;font-size:12px}.metrics{border:1px solid var(--line);background:var(--surface);border-radius:8px;grid-template-columns:repeat(4,minmax(0,1fr));margin-bottom:21px;padding:20px 0;display:grid}.metric{border-right:1px solid var(--stroke);min-width:0;padding:0 21px}.metric:last-child{border-right:0}.metric>span{color:var(--text-muted);justify-content:space-between;align-items:center;font-size:13px;display:flex}.metric>span svg{color:var(--text-muted)}.metric>strong{font-variant-numeric:tabular-nums;letter-spacing:-.5px;align-items:baseline;gap:8px;margin-top:13px;font-size:29px;font-weight:500;line-height:1.2;display:flex}.metric small{color:var(--text-muted);font-size:12px;font-weight:400}.metric p{color:var(--text-muted);margin:11px 0 0;font-size:12px;line-height:1.5}.metric .direction-metric{gap:15px;font-size:22px;line-height:1.58}.up,.down{color:var(--text-muted)}.charts-row{grid-template-columns:minmax(0,1.65fr) minmax(235px,1fr);gap:20px;display:grid}.chart-heading{padding-bottom:12px}.chart-heading .view-switch{flex-shrink:0}.view-switch button{padding:5px 9px;font-size:13px}.plot-toolbar{justify-content:space-between;align-items:center;margin:3px 0 7px;padding:0 21px;display:flex}.legend{color:var(--text-muted);align-items:center;gap:15px;font-size:12px;display:flex}.legend span{align-items:center;gap:6px;display:flex}.legend i{border-radius:50%;width:6px;height:6px;display:inline-block}.plot-toolbar select{background-color:var(--input-surface);color:var(--text);border:0;min-height:24px;padding:3px 8px;font-size:12px}.chart{width:100%;height:285px}.chart.heatmap{height:319px}.bar-legend{height:31px;padding:0 21px}.gene-chart-panel>.panel-heading{padding-bottom:10px}.chart-footnote{border-top:1px solid var(--stroke);color:var(--text-muted);align-items:center;gap:6px;min-height:39px;padding:12px 18px;font-size:12px;display:flex}.tiny-square{border:1px solid var(--stroke);width:5px;height:5px;transform:rotate(45deg)}.results-panel{margin-top:25px;scroll-margin-top:24px}.table-heading{padding:22px 24px}.count-badge{background:var(--surface);color:var(--text-muted);border-radius:4px;padding:3px 7px;font:13px ui-monospace,Consolas,monospace}.table-controls{align-items:center;gap:11px;display:flex}.search-box{border:1px solid var(--stroke);color:var(--text-muted);border-radius:5px;align-items:center;gap:9px;min-width:0;padding:9px 10px;display:flex}.search-box input{width:145px;min-width:0;color:var(--text);background:0 0;border:0;outline:0;font-size:13px}.search-box:focus-within{outline:2px solid var(--brand);outline-offset:2px}.table-controls select{min-height:34px;color:var(--text);font-size:13px}.table-scroll{scrollbar-width:thin;scrollbar-color:var(--scroll-thumb) var(--surface);max-height:426px;overflow:auto}.results-panel table{border-collapse:collapse;text-align:left;white-space:nowrap;width:100%;font-size:14px}.results-panel th{color:var(--text-muted);background:var(--surface-raised);border-top:1px solid var(--stroke);border-bottom:1px solid var(--stroke);z-index:1;padding:13px 24px;font-size:12px;font-weight:450;position:sticky;top:0}.results-panel th>span{color:var(--text-muted);margin-left:4px;font-size:12px}.results-panel td{border-bottom:1px solid var(--stroke);color:var(--text-muted);padding:14px 24px}.results-panel tr:last-child td{border-bottom:0}.gene-name{color:var(--text);font:550 12px ui-monospace,Consolas,monospace}.target-badge{color:var(--text-muted);background:var(--surface);border-radius:3px;margin-left:9px;padding:3px 5px;font-size:12px}.direction-badge{background:var(--surface);color:var(--text-muted);border-radius:4px;padding:4px 7px;font-size:12px}.up-badge,.down-badge{background:var(--surface);color:var(--text-muted)}.magnitude-track{background:var(--surface);border-radius:2px;width:83px;height:4px;overflow:hidden}.magnitude-track>div{opacity:.75;border-radius:2px;height:100%}.table-footer{border-top:1px solid var(--stroke);color:var(--text-muted);justify-content:space-between;align-items:center;gap:10px;padding:15px 24px;font-size:12px;display:flex}.table-footer button{color:var(--text-muted);background:0 0;border:0;align-items:center;gap:7px;font-size:12px;display:flex}.empty-state{text-align:center;color:var(--text-muted);padding:35px;font-size:14px}.empty-state h3{color:var(--text);font-weight:500}.empty-state .button{margin-top:10px}.methods{border-top:1px solid var(--stroke);grid-template-columns:1fr 1fr;gap:65px;margin:40px 0 35px;padding:26px 0 10px;scroll-margin-top:20px;display:grid}.methods h2{margin:10px 0 13px;font-size:19px;font-weight:500}.methods p{color:var(--text-muted);max-width:510px;font-size:14px;line-height:1.9}.methods a{color:var(--text-muted);margin-top:8px;font-size:13px;display:inline-block}.method-details details{border-bottom:1px solid var(--stroke);padding:13px 0}.method-details summary{cursor:pointer;color:var(--text-muted);font-size:14px}.method-details p{margin-bottom:4px;font-size:13px}.page-footer{border-top:1px solid var(--stroke);color:var(--text-muted);justify-content:space-between;padding:22px 0;font-size:12px;display:flex}.page-footer>span:first-child{color:var(--text-muted);letter-spacing:.3px;font-family:ui-monospace,Consolas,monospace}.mono{font-variant-numeric:tabular-nums;font-family:ui-monospace,SFMono-Regular,Consolas,monospace}@media (width>=1550px){main{padding:44px 50px 0}.chart{height:330px}.chart.heatmap{height:364px}.config-panel form{padding:26px 24px}.field-group{margin-bottom:28px}.metrics{padding:24px 0}}@media (width<=1250px){.sidebar{width:200px;padding-left:14px;padding-right:14px}.main-shell{width:calc(100% - 200px);margin-left:200px}main{padding:27px 26px 0}.topbar{padding:0 26px}.workbench{grid-template-columns:225px minmax(0,1fr);gap:16px}.charts-row{grid-template-columns:minmax(0,1fr)}.gene-chart-panel{display:none}.metric{padding:0 13px}.metric>strong{font-size:25px}.metric .direction-metric{gap:8px;font-size:19px}.methods{gap:35px}.table-controls{gap:7px}.search-box input{width:110px}.table-heading{padding:18px}.result-status{display:none}.chart{height:295px}.chart.heatmap{height:329px}}@media (width<=950px){.sidebar{align-items:center;width:76px;padding:27px 12px 0}.brand{margin:0 0 30px}.brand-name,.nav-label,.sidebar-divider,.presets,.sidebar-bottom,.sidebar-footer{display:none}.sidebar nav{flex-direction:column;gap:10px;display:flex}.nav-item{gap:0;padding:13px;font-size:0}.nav-dot{display:none}.main-shell{width:calc(100% - 76px);margin-left:76px}.metrics{gap:0}.methods h2{font-size:17px}.table-heading{align-items:flex-start}.table-controls{flex-direction:column;align-items:stretch}.table-controls select{width:100%}}@media (width<=700px){.sidebar{flex-direction:row;justify-content:space-between;width:100%;height:65px;padding:0 18px;position:relative}.brand{margin:0}.brand-logo{width:36px;height:36px}.brand-name{max-width:118px;font-size:16px;display:grid}.sidebar nav{flex-direction:row;gap:5px}.nav-item{margin:0;padding:10px}.app{display:block}.main-shell{width:100%;margin:0}.topbar{height:53px;padding:0 20px}.top-actions{gap:15px}.top-actions>a,.user-avatar{display:none}main{padding:23px 18px 0}.page-heading{align-items:flex-start;gap:12px}.page-heading .button{min-width:38px;padding:10px;font-size:0}.page-heading .button svg{width:18px}.page-heading h1{letter-spacing:0;font-size:24px}.intro{font-size:14px}.eyebrow{font-size:12px}.demo-notice{align-items:flex-start;padding:10px;font-size:13px}.demo-notice svg{margin-top:3px}.demo-notice a{display:none}.workbench{display:block}.config-panel{margin-bottom:22px}.config-panel form{grid-template-columns:1fr 1fr;gap:20px 16px;padding:20px;display:grid}.field-group{margin:0}.config-summary{grid-column:1/-1;margin:0}.config-note{align-self:center;margin:0}.run-button{min-height:42px}.result-heading{margin-bottom:13px}.metrics{grid-template-columns:repeat(2,minmax(0,1fr));row-gap:24px;padding:20px 0}.metric:nth-child(2){border-right:0}.metric{padding:0 20px}.metric>strong{font-size:28px}.metric p{font-size:13px}.metric>span{font-size:14px}.charts-row{gap:16px}.gene-chart-panel{display:block}.chart{height:270px}.chart.heatmap{height:304px}.table-heading{flex-direction:column;gap:17px}.table-controls{flex-direction:row;width:100%}.search-box{flex:1}.search-box input{width:100%}.table-controls select{width:auto}.table-footer{padding:13px 16px;font-size:12px}.table-footer button{white-space:nowrap}.methods{grid-template-columns:1fr;gap:14px;margin-top:30px}.methods p,.methods a,.method-details summary{font-size:14px}.page-footer{gap:15px;font-size:12px}.page-footer>span:last-child{display:none}}@media (prefers-reduced-motion:reduce){*{scroll-behavior:auto!important;transition:none!important}}.intro,.methods>div>p:not(.eyebrow){font-size:16px;line-height:1.8}.results-panel th{font-size:13px}.legend{font-size:12px}.chart-loading{min-height:415px;color:var(--text-muted);place-items:center;font-size:14px;display:grid}.sidebar-footer{font-size:11px}@media (width>=1251px){.chart{height:350px}.chart.heatmap{height:384px}.charts-row{align-items:stretch}}@media (width<=700px){.intro{font-size:14px}.config-note{font-size:12px}.table-footer{flex-wrap:wrap}.methods>div>p:not(.eyebrow){font-size:15px}}.app{--ink:var(--text);--muted:var(--text-muted);--accent:var(--brand);--line:var(--stroke);color:var(--ink);background:var(--canvas)}.sidebar{color:var(--text);border-right:1px solid var(--stroke);background:#eceef1;padding-top:26px}.brand{color:var(--text);margin-bottom:28px;font-weight:600}.nav-label,.presets small,.sidebar-footer{color:var(--text-soft);font-size:12px}.nav-item{color:var(--text-muted);min-height:44px}.nav-item:hover,.presets button:hover{background:var(--surface-raised);color:var(--text)}.nav-item.active{background:var(--accent-soft);color:var(--brand);box-shadow:inset 2px 0 var(--mint)}.nav-dot,.online-dot{background:var(--mint)}.sidebar-divider{background:var(--stroke)}.presets button{color:var(--text-muted)}.preset-dot{background:var(--mint)}.dot-1{background:var(--blue)}.dot-2{background:var(--amber)}.sidebar-bottom{padding-top:28px}.sidebar-bottom h3{color:var(--text);font-size:17px}.sidebar-bottom p{color:var(--text-muted)}.sidebar-bottom a,.small-orbit{color:var(--mint)}.sidebar-footer{border-color:var(--stroke);margin-top:auto}.sidebar-footer>span:last-child{font-size:12px}.topbar{background:var(--surface);border-color:var(--stroke);height:64px}.breadcrumb{color:var(--text-soft)}.breadcrumb strong{color:var(--text)}.top-actions>a{color:var(--text-muted)}.demo-tag{color:var(--mint)}.demo-tag>span{background:var(--mint)}.user-avatar{color:var(--brand);background:var(--accent-soft);border-color:var(--stroke)}main{padding-top:26px}.page-heading{margin-bottom:20px}.page-heading h1{letter-spacing:0;font-size:clamp(24px,2.2vw,32px);font-weight:550}.page-heading h1>span{color:var(--text)}.eyebrow,.page-heading .eyebrow{color:var(--text-soft);letter-spacing:.3px;font-size:12px}.page-heading .eyebrow{align-items:center;gap:8px;display:flex}.heading-orbit{border:1px solid var(--mint);border-radius:50%;width:8px;height:8px}.intro{color:var(--text-muted);font-size:16px}.button{border-radius:5px;min-height:42px}.secondary{background:var(--surface-raised);border-color:var(--stroke);color:var(--text-muted);box-shadow:none}.secondary:hover{background:var(--surface-hover);border-color:var(--stroke)}.primary{background:var(--brand);color:var(--on-brand);box-shadow:none}.primary:hover{background:var(--brand-hover)}.demo-notice{color:var(--text-muted);background:var(--surface-raised);border-color:var(--stroke);padding:11px 14px;font-size:14px}.demo-notice a{color:var(--mint)}.workbench{grid-template-columns:264px minmax(0,1fr);align-items:start;gap:22px}.panel{background:var(--surface);border-color:var(--stroke);box-shadow:none;border-radius:6px}.panel-heading h2{color:var(--text);font-size:17px}.panel-heading h2 svg{color:var(--text-muted)}.panel-heading p{color:var(--text-muted);font-size:14px}.config-panel>.panel-heading{background:var(--surface-raised);border-color:var(--stroke)}.config-panel form{padding:24px 22px 20px}.field-group label,.field-group legend{color:var(--text)}.step{background:var(--surface);border-color:var(--stroke);color:var(--text-muted)}.field-group select{background:var(--input-surface);border-color:var(--stroke-strong);color:var(--text);border-radius:7px;min-height:44px}.field-hint{color:var(--text-soft);font-size:13px}.segmented{background:var(--surface-raised);border-color:var(--stroke)}.segmented button{color:var(--text-muted)}.segmented button.selected{background:var(--accent-soft);color:var(--brand);border-color:var(--brand);box-shadow:none}.range-group output{color:var(--mint)}.range-group input{accent-color:var(--mint)}.range-labels{color:var(--text-soft)}.config-summary{color:var(--text-muted);border-color:var(--stroke);background:var(--surface-raised)}.config-summary small{color:var(--text-muted)}.config-note{color:var(--text-muted);font-size:13px}.config-note.pending{color:var(--amber)}.icon-button{color:var(--text-muted)}.icon-button:hover{background:var(--surface-hover);color:var(--mint)}.result-heading{color:var(--text-muted)}.result-heading strong{color:var(--text)}.result-status{color:var(--text-soft);font-size:13px}.outline-badge{color:var(--text-muted);border-color:var(--stroke);background:var(--surface)}.metrics{background:var(--surface);border-color:var(--stroke);border-radius:6px;margin-bottom:0}.metric{border-right-color:var(--stroke)}.metric>span{color:var(--text-muted);font-size:14px}.metric>strong{color:var(--text)}.metric p,.metric small{color:var(--text-soft);font-size:12px}.metric .direction-metric .up,.up{color:#a64e26}.metric .direction-metric .down,.down{color:#386995}.analysis-heading{justify-content:space-between;align-items:center;gap:15px;margin:30px 0 16px;display:flex}.analysis-heading h2{color:var(--text);margin:0;font-size:19px;font-weight:500}.analysis-heading>span{letter-spacing:1px;color:var(--text-soft);font:12px ui-monospace,monospace}.charts-row{grid-template-columns:minmax(0,1.55fr) minmax(280px,1fr);align-items:stretch;gap:22px}.gene-chart-panel{display:block}.legend,.chart-footnote{color:var(--text-muted);font-size:13px}.chart-footnote{border-color:var(--stroke)}.perturbed-dot{background:#79d8c0}.control-dot{background:#8ea8bc}.up-dot{background:#f0b888}.down-dot{background:#8fbaff}.plot-toolbar select{background:var(--input-surface);color:var(--text);font-size:14px}.count-badge,.target-badge{background:var(--accent-soft);color:var(--brand)}.gene-name{color:var(--text);font-size:14px}.results-panel th{background:var(--surface-raised);border-color:var(--stroke);color:var(--text-muted);font-size:14px}.results-panel td{color:var(--text-muted);border-color:var(--stroke)}.results-panel tr:hover td{background:var(--surface-hover)}.search-box{border-color:var(--stroke);background:var(--input-surface)}.search-box input,.table-controls select{color:var(--text);font-size:14px}.table-scroll{scrollbar-color:var(--scroll-thumb) var(--surface)}.table-footer{color:var(--text-muted);border-color:var(--stroke);font-size:13px}.table-footer button,.methods a{color:var(--mint);font-size:14px}.direction-badge{background:var(--surface);color:var(--text-muted)}.up-badge{color:#a64e26;background:#f7efe9}.down-badge{color:#386995;background:#eaf0f6}.magnitude-track{background:var(--surface-raised)}.methods{border-color:var(--stroke)}.methods .eyebrow{color:var(--text-soft)}.methods h2{color:var(--text)}.methods p,.method-details summary{color:var(--text-muted)}.method-details details{border-color:var(--stroke)}.page-footer{border-color:var(--stroke);color:var(--text-soft)}.page-footer>span:first-child,.empty-state,.chart-loading{color:var(--text-muted)}.empty-state h3{color:var(--text)}.muted{color:var(--text-muted)}.search-box:focus-within{outline-color:var(--mint)}@media (width>=1550px){.workbench{grid-template-columns:284px minmax(0,1fr)}}@media (width<=1250px){.workbench{grid-template-columns:245px minmax(0,1fr);gap:18px}.config-panel form{padding:22px 18px}.metrics{grid-template-columns:repeat(2,minmax(0,1fr));gap:22px 0}.metric:nth-child(2){border-right:0}.charts-row{grid-template-columns:minmax(0,1.25fr) minmax(255px,1fr);gap:18px}}@media (width<=950px){.charts-row{grid-template-columns:minmax(0,1fr)}}@media (width<=700px){.sidebar{padding-top:0}.topbar{height:52px}main{padding-top:20px}.page-heading h1{font-size:24px}.workbench{flex-direction:column;gap:20px;display:flex}.output-column{order:-1;width:100%}.config-panel{width:100%}.config-panel form{padding:20px}.metrics{row-gap:22px}.analysis-heading>span{display:none}.charts-row{gap:18px}.demo-notice{font-size:14px}.sidebar-bottom{display:none}}.archive-mode-switch{flex-wrap:wrap;align-items:center;gap:10px;margin-bottom:20px;display:flex}.archive-mode-switch button{border:1px solid var(--stroke-strong);background:var(--surface-raised);color:var(--text-muted);cursor:pointer;border-radius:7px;padding:10px 16px;font-size:14px}.archive-mode-switch button[aria-pressed=true]{color:var(--brand);background:var(--accent-soft);border-color:var(--brand)}.archive-mode-switch span{color:var(--text-muted);font-size:14px}.archive-workbench{color:var(--text);min-width:0;container:archive/inline-size}.context-entrance{min-height:calc(100vh - 70px);color:var(--text);align-content:center;padding:clamp(18px,3vw,50px) 0 70px;display:grid}.context-entrance>header{max-width:720px;margin-bottom:34px}.context-entrance>header>span,.context-entrance aside>span{color:var(--text-soft);letter-spacing:.14em;margin-bottom:11px;font:12px ui-monospace,monospace;display:block}.context-entrance h1{letter-spacing:-.055em;margin:0 0 16px;font-family:Avenir Next,Segoe UI Variable,Helvetica Neue,sans-serif;font-size:clamp(34px,4.5vw,62px);font-weight:470;line-height:1.02}.context-entrance h1 strong{font-weight:760}.context-entrance>header p{max-width:650px;color:var(--text-muted);margin:0;font-size:16px;line-height:1.75}.context-entrance-grid{grid-template-columns:repeat(4,minmax(0,1fr));gap:12px;display:grid}.context-entrance-grid button{--context-color:#79d8c0;text-align:left;min-height:280px;color:var(--text);background:var(--surface);border:1px solid var(--stroke);cursor:pointer;border-radius:7px;grid-template-rows:auto auto auto auto 1fr auto;align-content:start;justify-items:start;padding:22px;transition:transform .2s,border-color .2s,box-shadow .2s,background .2s;display:grid}.context-entrance-grid button[data-line=RPE1]{--context-color:#8fbfff}.context-entrance-grid button[data-line=Jurkat]{--context-color:#c2adf3}.context-entrance-grid button[data-line=HepG2]{--context-color:#ecc28b}.context-entrance-grid button:hover{border-color:var(--brand);background:var(--surface-hover);transform:translateY(-4px);box-shadow:0 15px 34px #25384912}.context-entrance-index{color:var(--text-soft);justify-self:end;font:12px ui-monospace,monospace}.context-entrance-mark{background:var(--context-color);width:13px;height:13px;box-shadow:0 0 0 6px color-mix(in srgb,var(--context-color) 20%,transparent);border-radius:50%;margin:25px 0 17px}.context-entrance-grid button>strong{letter-spacing:-.03em;font:26px ui-monospace,monospace}.context-entrance-role{color:var(--text-muted);margin-top:8px;font-size:13px}.context-entrance-grid p{color:var(--text-muted);margin:18px 0 24px;font-size:14px;line-height:1.7}.context-entrance-action{color:var(--brand);align-self:end;font-size:14px;font-weight:650}.context-entrance-action b{margin-left:5px;font-size:17px;font-weight:500;transition:margin-left .2s}.context-entrance-grid button:hover .context-entrance-action b{margin-left:10px}.context-entrance>aside{border-top:1px solid var(--stroke);grid-template-columns:150px minmax(0,1fr);align-items:start;gap:22px;margin-top:26px;padding-top:20px;display:grid}.context-entrance aside>span{margin:3px 0 0}.context-entrance aside p{max-width:620px;color:var(--text-muted);margin:0;font-size:13px;line-height:1.7}.archive-intro{justify-content:space-between;align-items:center;gap:20px;margin:0 0 20px;display:flex}.archive-intro p,.archive-section-heading>div>p{color:var(--text-soft);letter-spacing:.3px;margin:0 0 10px;font:12px ui-monospace,monospace}.archive-intro h1{letter-spacing:-.052em;align-items:baseline;gap:.24em;margin:0;font-family:Avenir Next,Segoe UI Variable,Helvetica Neue,sans-serif;font-size:clamp(28px,2.6vw,38px);line-height:1.05;display:flex}.archive-intro h1>span:first-child{font-weight:750}.archive-intro h1>span:last-child{letter-spacing:-.045em;font-weight:480}.archive-intro>div>span,.archive-section-heading>div>span{color:var(--text-muted);font-size:14px;line-height:1.7}.archive-live-tag{border:1px solid var(--stroke);color:var(--text-muted);white-space:nowrap;background:0 0;border-radius:4px;padding:8px 12px;font-size:13px}.archive-guide{width:min(720px,100vw - 32px);max-height:min(850px,100vh - 32px);color:var(--text);background:var(--surface);border:1px solid var(--stroke-strong);border-radius:10px;padding:0;box-shadow:0 24px 70px #18233335}.archive-guide::backdrop{-webkit-backdrop-filter:blur(3px);backdrop-filter:blur(3px);background:#10223080}.archive-guide-shell{padding:28px}.archive-guide-shell>header{border-bottom:1px solid var(--stroke);justify-content:space-between;align-items:flex-start;gap:24px;padding-bottom:20px;display:flex}.archive-guide-shell>header span{color:var(--text-soft);letter-spacing:.12em;margin-bottom:7px;font:12px ui-monospace,monospace;display:block}.archive-guide-shell h2{letter-spacing:-.025em;margin:0;font-size:25px;font-weight:600}.archive-guide-close{border:1px solid var(--stroke);width:34px;height:34px;color:var(--text-muted);background:var(--surface-raised);cursor:pointer;border-radius:50%;padding:0;font-size:22px;line-height:1}.archive-guide ol{gap:0;margin:0;padding:8px 0;list-style:none;display:grid}.archive-guide li{border-bottom:1px solid var(--stroke);grid-template-columns:42px minmax(0,1fr);gap:14px;padding:15px 0;display:grid}.archive-guide li>span{color:var(--brand);padding-top:2px;font:13px ui-monospace,monospace}.archive-guide li strong{margin-bottom:5px;font-size:15px;font-weight:600;display:block}.archive-guide li p,.archive-guide aside p{color:var(--text-muted);margin:0;font-size:14px;line-height:1.7}.archive-guide aside{border-left:3px solid var(--brand);background:var(--accent-soft);margin-top:12px;padding:15px 17px}.archive-guide aside strong{margin-bottom:5px;font-size:14px;display:block}.archive-guide-done{color:#fff;background:var(--brand);cursor:pointer;border:0;border-radius:5px;width:100%;margin-top:18px;padding:12px 18px;font-size:14px;font-weight:650}.archive-casebar{border:1px solid var(--stroke);background:var(--surface);border-radius:10px;justify-content:space-between;align-items:center;gap:24px;padding:16px 20px;display:flex}.archive-casebar strong{color:var(--text);font-size:14px;font-weight:500}.archive-casebar>div>div{flex-wrap:wrap;gap:8px;margin-top:10px;display:flex}.archive-casebar button{background:var(--surface-raised);color:var(--text-muted);border:1px solid var(--stroke-strong);cursor:pointer;border-radius:7px;padding:7px 16px;font:15px ui-monospace,monospace}.archive-casebar button[aria-pressed=true]{background:var(--accent-soft);color:var(--brand);border-color:var(--brand)}.archive-casebar p,.archive-notice{color:var(--text-muted);font-size:14px;line-height:1.8}.archive-notice{margin:12px 0 18px;padding:0 2px}.archive-notice summary{color:var(--text-muted);padding:6px 0;font-size:13px}.archive-notice p{background:var(--surface-raised);border-left:2px solid var(--stroke);border-radius:0 6px 6px 0;margin:6px 0 0;padding:10px 14px}.archive-evidence{border:0;border-top:1px solid var(--stroke);background:0 0;border-radius:0;min-width:0;margin:28px 0;padding:28px 0;scroll-margin-top:85px}.archive-evidence .quality-scorecards{margin-top:22px}.archive-evidence .quality-scorecards>div{background:var(--surface-raised);border-color:var(--stroke);min-width:0}.archive-evidence .patch-dimensions{background:var(--surface-raised);grid-template-columns:minmax(0,1fr) 20px minmax(0,1fr) 20px minmax(0,1fr)}.archive-evidence .patch-grid{grid-template-columns:repeat(auto-fill,minmax(30px,1fr))}.archive-section-heading{justify-content:space-between;align-items:center;gap:18px;margin-bottom:18px;display:flex}.archive-section-heading h2{margin:0 0 8px;font-size:22px;font-weight:550}.archive-section-heading h3{margin:10px 0;font-size:18px;font-weight:550}.archive-evidence button,.archive-evidence select{color:var(--text);background:var(--input-surface);border:1px solid var(--stroke-strong);cursor:pointer;border-radius:6px;padding:8px 12px;font-size:14px}.archive-evidence label{color:var(--text-muted);align-items:center;gap:10px;font-size:14px;display:flex}.archive-evidence select{max-width:100%}.archive-table-scroll{border:1px solid var(--stroke);scrollbar-color:var(--scroll-thumb) var(--surface);border-radius:8px;overflow-x:auto}.archive-table-scroll table{border-collapse:collapse;white-space:nowrap;width:100%;font-size:14px}.archive-table-scroll th{text-align:left;color:var(--text-muted);font-weight:500}.archive-table-scroll thead th{background:var(--surface-raised);font-size:14px}.archive-table-scroll tbody th{background:var(--surface-raised);color:var(--text-muted);position:static}.archive-table-scroll tbody tr:hover>td,.archive-table-scroll tbody tr:hover>th{background:var(--surface-hover)}.archive-table-scroll td,.archive-table-scroll th{border-bottom:1px solid var(--stroke);padding:12px}.archive-table-scroll td{color:var(--text-muted);background:var(--surface);font-family:ui-monospace,monospace}.archive-provenance-grid{grid-template-columns:repeat(3,minmax(0,1fr));gap:25px;display:grid}.archive-provenance-grid h3{color:var(--text);font-size:16px;font-weight:500}.archive-provenance-grid p{color:var(--text-muted);font-size:14px;line-height:1.9}.archive-empty{min-height:250px;color:var(--text-muted);background:var(--surface);border:1px solid var(--stroke);border-radius:12px;place-content:center;padding:30px;display:grid}.archive-empty button{background:var(--surface-raised);color:var(--text-muted);cursor:pointer;border:0;border-radius:6px;justify-self:center;padding:10px 18px}.archive-workbench button:disabled{opacity:.45;cursor:not-allowed}.archive-workbench .prior-method-detail p,.archive-workbench .rna-note{overflow-wrap:anywhere}.archive-workbench .cell-atlas{width:100%}.archive-contexts{grid-template-columns:repeat(4,minmax(0,1fr));gap:10px;margin:0 0 16px;display:grid}.archive-contexts button{--context-color:#79d8c0;text-align:left;background:var(--surface);color:var(--text-muted);border:1px solid var(--stroke);cursor:pointer;border-radius:5px;grid-template-columns:auto 1fr;align-items:center;gap:8px;padding:15px 16px;transition:background .18s,border-color .18s;display:grid}.archive-contexts button[data-line=RPE1]{--context-color:#8fbfff}.archive-contexts button[data-line=Jurkat]{--context-color:#c2adf3}.archive-contexts button[data-line=HepG2]{--context-color:#ecc28b}.archive-contexts button:hover{background:var(--surface-hover);border-color:var(--stroke-strong)}.archive-contexts button[aria-pressed=true]{border-color:var(--brand);background:var(--accent-soft);box-shadow:inset 2px 0 var(--brand)}.archive-contexts strong{color:var(--text);align-items:center;gap:9px;font:18px ui-monospace,monospace;display:flex}.archive-contexts strong:before{content:"";background:var(--context-color);border-radius:50%;flex-shrink:0;width:8px;height:8px;box-shadow:0 0 0 1px #242a3130}.archive-contexts span{color:var(--text-muted);text-align:right;font-size:12px}.atlas-header .archive-scene-status{color:var(--text-muted);margin:8px 0 0;padding:0;font-size:14px;line-height:1.6}.archive-retry{align-items:center;gap:14px;margin:16px 0;display:flex}.archive-retry button{background:var(--surface-raised);color:var(--text-muted);border:0;border-radius:6px;padding:8px 12px}@media (width<=1100px){.archive-contexts,.context-entrance-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.context-entrance-grid button{min-height:240px}}@media (width<=420px){.archive-contexts{grid-template-columns:1fr}}@media (width<=850px){.archive-provenance-grid{grid-template-columns:1fr;gap:8px}.archive-evidence{padding:20px}}@media (width<=600px){.context-entrance{align-content:start;padding-top:26px}.context-entrance-grid{grid-template-columns:1fr}.context-entrance-grid button{min-height:220px}.context-entrance>aside{grid-template-columns:1fr;gap:5px}.archive-intro,.archive-casebar,.archive-section-heading{flex-direction:column;align-items:flex-start}.archive-intro{gap:12px}.archive-casebar{gap:8px}.archive-casebar p{margin-bottom:0}.archive-evidence{padding:16px}.archive-guide-shell{padding:21px}}@container archive (width<=700px){.archive-evidence .quality-scorecards{grid-template-columns:repeat(2,minmax(0,1fr));gap:10px}.archive-evidence .quality-scorecards>div{padding:14px 12px}.archive-evidence .quality-scorecards strong{font-size:26px}.archive-evidence .patch-dimensions strong{font-size:20px}}@container archive (width<=430px){.archive-evidence .patch-dimensions{grid-template-columns:minmax(0,1fr);gap:14px}.archive-evidence .patch-dimensions>b{justify-self:center;transform:rotate(90deg)}.archive-evidence .quality-scorecards strong{font-size:23px}}.archive-lab-layout{grid-template-columns:minmax(0,1fr);align-items:start;gap:20px;display:grid}.archive-generation-rail,.archive-exploration{min-width:0}.archive-generation-rail .generation-panel{margin:0 0 14px}.archive-generation-rail .archive-notice{margin-bottom:0}.archive-exploration .cell-atlas{box-shadow:none;margin-bottom:0}.archive-generation-rail .generation-gene{z-index:10;position:relative}@container archive (width>=1000px){.archive-lab-layout{grid-template-columns:260px minmax(0,1fr);gap:20px}.archive-generation-rail{border:1px solid var(--stroke);background:#f8f9fa;border-radius:6px;align-self:stretch}.archive-generation-rail .generation-panel{background:0 0;border:0;border-radius:0;margin:0;padding:20px 18px 0}.archive-generation-rail .generation-heading{flex-direction:column;align-items:flex-start;gap:14px;margin-bottom:22px}.archive-generation-rail .generation-device{overflow-wrap:anywhere;border:0;border-radius:5px;max-width:100%;padding:6px 9px;line-height:1.6}.archive-generation-rail .generation-form{grid-template-columns:minmax(0,1fr);gap:17px}.archive-generation-rail .generation-form>*{grid-column:1}.archive-generation-rail .generation-form input,.archive-generation-rail .generation-form select{border-color:var(--stroke-strong)}.archive-generation-rail .generation-gene>span{font-size:13px;line-height:1.6}.archive-generation-rail .rna-search-results button{overflow-wrap:anywhere;flex-direction:column;align-items:flex-start;gap:4px}.archive-generation-rail .rna-search-results button span{overflow-wrap:anywhere;max-width:100%}.archive-generation-rail .generation-submit{min-height:46px;margin-top:5px}.archive-generation-rail .generation-note{margin:16px 0;font-size:12px;line-height:1.9}.archive-generation-rail .generation-history-heading{flex-direction:column;align-items:stretch;gap:8px}.archive-generation-rail .generation-history>summary{flex-wrap:wrap;gap:8px}.archive-generation-rail .generation-jobs{scrollbar-color:var(--scroll-thumb) var(--surface);scrollbar-width:thin;max-height:430px;overflow-y:auto}.archive-generation-rail .generation-job{border:0;border-left:2px solid var(--stroke);background:var(--surface);border-radius:0;grid-template-columns:minmax(0,1fr);gap:10px;padding:12px}.archive-generation-rail .generation-job.is-selected{border-color:var(--brand);background:var(--accent-soft)}.archive-generation-rail .generation-job button{justify-self:start}.archive-generation-rail .generation-job>div{overflow-wrap:anywhere;min-width:0}.archive-generation-rail .archive-casebar{border:0;border-top:1px solid var(--stroke);background:0 0;border-radius:0;flex-direction:column;align-items:stretch;gap:8px;margin-top:0;padding:18px}.archive-generation-rail .archive-casebar strong{color:var(--text);line-height:1.7}.archive-generation-rail .archive-casebar button{padding:7px 10px;font-size:14px}.archive-generation-rail .archive-casebar p{margin:8px 0 0;font-size:12px;line-height:1.8}.archive-generation-rail .archive-notice{margin:0;padding:0 18px 16px}.archive-generation-rail .archive-notice summary{font-size:12px;line-height:1.8}.archive-generation-rail .archive-notice p{overflow-wrap:anywhere;padding:10px;font-size:12px}}.archive-method-group{border:1px solid var(--stroke);background:var(--surface);border-radius:6px;margin:12px 0}.archive-method-group>summary{cursor:pointer;color:var(--text);padding:16px 18px;font-size:15px}.archive-method-group[open]>summary{border-bottom:1px solid var(--stroke)}.archive-method-group>.archive-evidence{margin:0}.archive-provenance{margin-top:28px}.archive-exploration{scroll-margin-top:80px}